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Thursday, May 26, 2005
If anyone reads this blog regularly, he will find this vaguely related to thoughts I have.
Expression cloning of a protective Leishmania antigen.
Science. 1995 Apr 28;268(5210):563-6.Parasite-specific CD4+ T cells have been shown to transfer protection against Leishmania major in susceptible BALB/c mice. An epitope-tagged expression library was used to identify the antigen recognized by a protective CD4+ T cell clone. The expression library allowed recombinant proteins made in bacteria to be captured by macrophages for presentation to T cells restricted to major histocompatibility complex class II. A conserved 36-kilodalton member of the tryptophan-aspartic acid repeat family of proteins was identified that was expressed in both stages of the parasite life cycle. A 24-kilodalton portion of this antigen protected susceptible mice when administered as a vaccine with interleukin-12 before infection.
The principal difference is that this is a report of something that was actually done and which worked. It sounds very exciting to me. The weird thing is the list of authors
Mougneau E, Altare F, Wakil AE, Zheng S, Coppola T, Wang ZE, Waldmann R, Locksley RM, Glaichenhaus N.
As far as I know, the R Waldmann who actually did something useful related to vaccines against parisites based on expression libraries is not a relative of the R Waldmann who is writing this.
This is spooky.
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